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Nov. 17, 2021 –The traditional recommendation to “feed a chilly, starve a fever” has a restricted proof base, however new analysis highlights how feeding fats and sugar to a tumor might gasoline its development.
Pancreatic tumors in mice develop extra slowly when the animals eat a calorie-restricted eating regimen, findings counsel. The outcomes, revealed in Nature, don’t imply that anybody with most cancers ought to embark on a particular eating regimen, particularly given that individuals aren’t mice. However extra analysis on this space might determine mixtures of specifics diets and drug therapies that improve most cancers therapies.
Scientists have lengthy identified that most cancers cells are ravenous, consuming a great deal of glucose as they develop. The query is whether or not ravenous them of glucose would gradual this development with out harming the remainder of the physique. To get a solution, the researchers labored with mice carrying pancreatic tumors. They fed a low-calorie eating regimen to at least one group, a traditional eating regimen to at least one group, and a high-protein, high-fat, low-carbohydrate ketogenic eating regimen to a 3rd group.
Solely tumors in animals consuming the low-calorie eating regimen confirmed slower development, implying that the tumors wanted greater than glucose to continue to grow. Glucose ranges had been decrease with each calorie restriction and the keto eating regimen, however lipids additionally had been decrease with calorie restriction.
All cells, together with most cancers cells, use lipids to construct their protecting outer membranes. The elevated lipid ranges within the keto eating regimen might have given tumors all of the lipids they wanted to construct new cell membranes.
The outcomes counsel that the important thing to slowing most cancers in these mice was to starve tumors of each glucose and lipids, as solely the calorie-restricted eating regimen did. The wholesome tissues of the physique nonetheless want these vitamins, one cause sufferers with most cancers shouldn’t change their diets with out scientific steerage. However the findings trace that utilizing eating regimen or medication to limit consumption of some lipids or their use cells may very well be a path to ravenous a tumor with out ravenous the individual.
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